A human monoclonal antibody with neutralizing activity against highly divergent influenza subtypes.
Identifieur interne : 000061 ( 1968/Analysis ); précédent : 000060; suivant : 000062A human monoclonal antibody with neutralizing activity against highly divergent influenza subtypes.
Auteurs : Nicola Clementi [Italie] ; Donata De Marco ; Nicasio Mancini ; Laura Solforosi ; Guisella J. Moreno ; Larisa V. Gubareva ; Vasiliy Mishin ; Andrea Di Pietro ; Elisa Vicenzi ; Antonio G. Siccardi ; Massimo Clementi ; Roberto BurioniSource :
- PloS one [ 1932-6203 ] ; 2011.
Descripteurs français
- KwdFr :
- Alanine (génétique), Analyse de regroupements, Animaux, Anticorps monoclonaux (), Anticorps neutralisants (), Chiens, Conformation moléculaire, Glycoprotéines (), Grippe humaine (), Grippe humaine (métabolisme), Humains, Hémagglutinines virales (), Liaison aux protéines, Lignée cellulaire, Modèles moléculaires, Mutagenèse dirigée, Orthomyxoviridae (génétique), Orthomyxoviridae (immunologie), Phylogénie, Tests de neutralisation, Vaccins antigrippaux (usage thérapeutique).
- MESH :
- génétique : Alanine, Orthomyxoviridae.
- immunologie : Orthomyxoviridae.
- métabolisme : Grippe humaine.
- usage thérapeutique : Vaccins antigrippaux.
- Analyse de regroupements, Animaux, Anticorps monoclonaux, Anticorps neutralisants, Chiens, Conformation moléculaire, Glycoprotéines, Grippe humaine, Humains, Hémagglutinines virales, Liaison aux protéines, Lignée cellulaire, Modèles moléculaires, Mutagenèse dirigée, Phylogénie, Tests de neutralisation.
English descriptors
- KwdEn :
- Alanine (genetics), Animals, Antibodies, Monoclonal (chemistry), Antibodies, Neutralizing (chemistry), Cell Line, Cluster Analysis, Dogs, Glycoproteins (chemistry), Hemagglutinins, Viral (chemistry), Humans, Influenza Vaccines (therapeutic use), Influenza, Human (metabolism), Influenza, Human (prevention & control), Models, Molecular, Molecular Conformation, Mutagenesis, Site-Directed, Neutralization Tests, Orthomyxoviridae (genetics), Orthomyxoviridae (immunology), Phylogeny, Protein Binding.
- MESH :
- chemical , chemistry : Antibodies, Monoclonal, Antibodies, Neutralizing, Glycoproteins, Hemagglutinins, Viral.
- chemical , genetics : Alanine.
- chemical , therapeutic use : Influenza Vaccines.
- genetics : Orthomyxoviridae.
- immunology : Orthomyxoviridae.
- metabolism : Influenza, Human.
- prevention & control : Influenza, Human.
- Animals, Cell Line, Cluster Analysis, Dogs, Humans, Models, Molecular, Molecular Conformation, Mutagenesis, Site-Directed, Neutralization Tests, Phylogeny, Protein Binding.
Abstract
The interest in broad-range anti-influenza A monoclonal antibodies (mAbs) has recently been strengthened by the identification of anti-hemagglutinin (HA) mAbs endowed with heterosubtypic neutralizing activity to be used in the design of "universal" prophylactic or therapeutic tools. However, the majority of the single mAbs described to date do not bind and neutralize viral isolates belonging to highly divergent subtypes clustering into the two different HA-based influenza phylogenetic groups: the group 1 including, among others, subtypes H1, H2, H5 and H9 and the group 2 including, among others, H3 subtype. Here, we describe a human mAb, named PN-SIA28, capable of binding and neutralizing all tested isolates belonging to phylogenetic group 1, including H1N1, H2N2, H5N1 and H9N2 subtypes and several isolates belonging to group 2, including H3N2 isolates from the first period of the 1968 pandemic. Therefore, PN-SIA28 is capable of neutralizing isolates belonging to subtypes responsible of all the reported pandemics, as well as other subtypes with pandemic potential. The region recognized by PN-SIA28 has been identified on the stem region of HA and includes residues highly conserved among the different influenza subtypes. A deep characterization of PN-SIA28 features may represent a useful help in the improvement of available anti-influenza therapeutic strategies and can provide new tools for the development of universal vaccinal strategies.
DOI: 10.1371/journal.pone.0028001
PubMed: 22162996
Affiliations:
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pubmed:22162996Le document en format XML
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Moreno</name></author><author><name sortKey="Gubareva, Larisa V" sort="Gubareva, Larisa V" uniqKey="Gubareva L" first="Larisa V" last="Gubareva">Larisa V. Gubareva</name></author><author><name sortKey="Mishin, Vasiliy" sort="Mishin, Vasiliy" uniqKey="Mishin V" first="Vasiliy" last="Mishin">Vasiliy Mishin</name></author><author><name sortKey="Di Pietro, Andrea" sort="Di Pietro, Andrea" uniqKey="Di Pietro A" first="Andrea" last="Di Pietro">Andrea Di Pietro</name></author><author><name sortKey="Vicenzi, Elisa" sort="Vicenzi, Elisa" uniqKey="Vicenzi E" first="Elisa" last="Vicenzi">Elisa Vicenzi</name></author><author><name sortKey="Siccardi, Antonio G" sort="Siccardi, Antonio G" uniqKey="Siccardi A" first="Antonio G" last="Siccardi">Antonio G. Siccardi</name></author><author><name sortKey="Clementi, Massimo" sort="Clementi, Massimo" uniqKey="Clementi M" first="Massimo" last="Clementi">Massimo Clementi</name></author><author><name sortKey="Burioni, Roberto" sort="Burioni, Roberto" uniqKey="Burioni R" first="Roberto" last="Burioni">Roberto Burioni</name></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alanine (genetics)</term><term>Animals</term><term>Antibodies, Monoclonal (chemistry)</term><term>Antibodies, Neutralizing (chemistry)</term><term>Cell Line</term><term>Cluster Analysis</term><term>Dogs</term><term>Glycoproteins (chemistry)</term><term>Hemagglutinins, Viral (chemistry)</term><term>Humans</term><term>Influenza Vaccines (therapeutic use)</term><term>Influenza, Human (metabolism)</term><term>Influenza, Human (prevention & control)</term><term>Models, Molecular</term><term>Molecular Conformation</term><term>Mutagenesis, Site-Directed</term><term>Neutralization Tests</term><term>Orthomyxoviridae (genetics)</term><term>Orthomyxoviridae (immunology)</term><term>Phylogeny</term><term>Protein Binding</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Alanine (génétique)</term><term>Analyse de regroupements</term><term>Animaux</term><term>Anticorps monoclonaux ()</term><term>Anticorps neutralisants ()</term><term>Chiens</term><term>Conformation moléculaire</term><term>Glycoprotéines ()</term><term>Grippe humaine ()</term><term>Grippe humaine (métabolisme)</term><term>Humains</term><term>Hémagglutinines virales ()</term><term>Liaison aux protéines</term><term>Lignée cellulaire</term><term>Modèles moléculaires</term><term>Mutagenèse dirigée</term><term>Orthomyxoviridae (génétique)</term><term>Orthomyxoviridae (immunologie)</term><term>Phylogénie</term><term>Tests de neutralisation</term><term>Vaccins antigrippaux (usage thérapeutique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Antibodies, Neutralizing</term><term>Glycoproteins</term><term>Hemagglutinins, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Alanine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Alanine</term><term>Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Cluster Analysis</term><term>Dogs</term><term>Humans</term><term>Models, Molecular</term><term>Molecular Conformation</term><term>Mutagenesis, Site-Directed</term><term>Neutralization Tests</term><term>Phylogeny</term><term>Protein Binding</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de regroupements</term><term>Animaux</term><term>Anticorps monoclonaux</term><term>Anticorps neutralisants</term><term>Chiens</term><term>Conformation moléculaire</term><term>Glycoprotéines</term><term>Grippe humaine</term><term>Humains</term><term>Hémagglutinines virales</term><term>Liaison aux protéines</term><term>Lignée cellulaire</term><term>Modèles moléculaires</term><term>Mutagenèse dirigée</term><term>Phylogénie</term><term>Tests de neutralisation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The interest in broad-range anti-influenza A monoclonal antibodies (mAbs) has recently been strengthened by the identification of anti-hemagglutinin (HA) mAbs endowed with heterosubtypic neutralizing activity to be used in the design of "universal" prophylactic or therapeutic tools. However, the majority of the single mAbs described to date do not bind and neutralize viral isolates belonging to highly divergent subtypes clustering into the two different HA-based influenza phylogenetic groups: the group 1 including, among others, subtypes H1, H2, H5 and H9 and the group 2 including, among others, H3 subtype. Here, we describe a human mAb, named PN-SIA28, capable of binding and neutralizing all tested isolates belonging to phylogenetic group 1, including H1N1, H2N2, H5N1 and H9N2 subtypes and several isolates belonging to group 2, including H3N2 isolates from the first period of the 1968 pandemic. Therefore, PN-SIA28 is capable of neutralizing isolates belonging to subtypes responsible of all the reported pandemics, as well as other subtypes with pandemic potential. The region recognized by PN-SIA28 has been identified on the stem region of HA and includes residues highly conserved among the different influenza subtypes. A deep characterization of PN-SIA28 features may represent a useful help in the improvement of available anti-influenza therapeutic strategies and can provide new tools for the development of universal vaccinal strategies.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><noCountry><name sortKey="Burioni, Roberto" sort="Burioni, Roberto" uniqKey="Burioni R" first="Roberto" last="Burioni">Roberto Burioni</name><name sortKey="Clementi, Massimo" sort="Clementi, Massimo" uniqKey="Clementi M" first="Massimo" last="Clementi">Massimo Clementi</name><name sortKey="De Marco, Donata" sort="De Marco, Donata" uniqKey="De Marco D" first="Donata" last="De Marco">Donata De Marco</name><name sortKey="Di Pietro, Andrea" sort="Di Pietro, Andrea" uniqKey="Di Pietro A" first="Andrea" last="Di Pietro">Andrea Di Pietro</name><name sortKey="Gubareva, Larisa V" sort="Gubareva, Larisa V" uniqKey="Gubareva L" first="Larisa V" last="Gubareva">Larisa V. Gubareva</name><name sortKey="Mancini, Nicasio" sort="Mancini, Nicasio" uniqKey="Mancini N" first="Nicasio" last="Mancini">Nicasio Mancini</name><name sortKey="Mishin, Vasiliy" sort="Mishin, Vasiliy" uniqKey="Mishin V" first="Vasiliy" last="Mishin">Vasiliy Mishin</name><name sortKey="Moreno, Guisella J" sort="Moreno, Guisella J" uniqKey="Moreno G" first="Guisella J" last="Moreno">Guisella J. Moreno</name><name sortKey="Siccardi, Antonio G" sort="Siccardi, Antonio G" uniqKey="Siccardi A" first="Antonio G" last="Siccardi">Antonio G. Siccardi</name><name sortKey="Solforosi, Laura" sort="Solforosi, Laura" uniqKey="Solforosi L" first="Laura" last="Solforosi">Laura Solforosi</name><name sortKey="Vicenzi, Elisa" sort="Vicenzi, Elisa" uniqKey="Vicenzi E" first="Elisa" last="Vicenzi">Elisa Vicenzi</name></noCountry><country name="Italie"><noRegion><name sortKey="Clementi, Nicola" sort="Clementi, Nicola" uniqKey="Clementi N" first="Nicola" last="Clementi">Nicola Clementi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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